Rattray is a major contributor to research reported in BMC Genomics that describes the group’s newly developed method for genome-wide sequencing of DNA palindromes in a cancer cell line. The arrangement turned out to be a DNA palindrome, “opening the door to studying these elusive DNA motifs,” she said.Ī staff scientist in GRCBL, NCI Center for Cancer Research, Rattray said that, while their discovery occurred a number of years ago, their group continues to study DNA repair and rearrangements that result in abnormal repair “because of the association with certain cancers.” The group’s goal is to better understand the origin of these rearrangements, she added. The DNA exhibited a “very specific, but weird, rearrangement,” she explained. When Alison Rattray and colleagues in the Gene Regulation and Chromosome Biology Laboratory (GRCBL) examined a mutant yeast cell they had isolated in a screen, they noticed something strange. Craig Reynolds, associate director, National Cancer Institute, from among the most recently published Platinum Publications. Editor's note: Platinum Highlight articles are noteworthy publications selected periodically by Dr.

6 base palindromic sequence